Working Groups

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Current Officers


Jason Roberts


Stefan Hagel


Hafiz Abdul-Aziz


Despoina Koulenti

All Members

Massimo Antonelli (Italy)
Georgios Dimopoulos (Greece)
Hakan Erdem (Turkey)
Igor Karpov (Belarus)
Alain Lepape (France)
Jeffrey Lipman (Australia)
Jose-Artur Paiva (Portugal)
Mathias Pletz (Germnay)
Rosana Richtmann (Brazil)
Vladimir Rudnov (Russia)
Kordo Saeed (UK)

How to Join

Members of an ISAC Member Society are eligible to join any of our Working Groups. If you are a member and would like to join this group, please contact Fee Johnstone, ISAC Executive Assistant at

Aims and Objectives

Infections in the intensive care unit (ICU) represent the nosocomial infections of the near future as it is predicted that hospitals of the future will be transformed into massive ICUs and other units providing increased levels of care. Generally, patients who are transferred from the ICU to hospital wards are colonised with antimicrobial-resistant bacteria, providing a focus for spread and colonization of the whole hospital. Thus, today’s ICUs are of major concern regarding both prevention and therapy of the nosocomial infections arising in their environment. Ventilation associated pneumonia (VAP) and central catheter-associated infections represent the majority of ICU infections, with mortality rates exceeding 30%. The principle causes are multi-resistant strains of Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella species producing ESBLs, MRSA and VRE strains.

This Working Group aims to:

  • Enhance the epidemiological surveillance of nosocomial ICU infections
  • Promote antibiotic resistant surveillance in ICUs
  • Evaluate therapeutic decisions in the ICU. These include antibiotic rotation, restriction and de-escalation policies, in order to prevent and/or reduce resistance rates by applying well-organised protocols
  • Evaluate the validity of surveillance cultures as a guide to empirical antimicrobial therapy
  • Promote the implementation of “hand-hygiene protocols”.

Projects / Publications

2020 Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper.
Abdul-Aziz MH, Alffenaar JC, Bassetti M et al on behalf of Infection Section of European Society of Intensive Care Medicine (ESICM); Pharmacokinetic/pharmacodynamic and Critically Ill Patient Study Groups of European Society of Clinical Microbiology and Infectious Diseases (ESCMID); Infectious Diseases Group of International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT); Infections in the ICU and Sepsis Working Group of International Society of Antimicrobial Chemotherapy (ISAC).
Intensive Care Med. 2020 May 7. doi: 10.1007/s00134-020-06050-1. [Epub ahead of print]
The Screening of Antifungal Exposure in ICU (SAFE-ICU) Study
2017 Infections in the ICU & Sepsis Annual Report 2017


Nov 2019 Two symposia sessions at the 31st ICC - 4th GCCMID in Dubai
24-27 Nov 2017 30th International Congress of Chemotherapy & Infection (ICC)

Future / Ongoing Projects

  • Developing a Consensus Statement on Antimicrobial Therapeutic Drug Monitoring in Critically Ill Patients
  • The Screening of Antifungal Exposure in ICU (SAFE-ICU) Study

Last updated: May 14th-2020