Working Groups

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Current Officers

D McIntosh


David McIntosh

H Mikamo


Hiroshige Mikamo

S Unal


Serhat Unal

M Ramirez


Mario Ramirez

All Members

Chris Blyth (Australia)
Pablo Bonvehi (Argentian)
Cheng-Hsun Chiu (Taiwan)
Chih-Hsien Chuang (Taiwan)
Robert Cohen (France)
Ron Dagan (Israel)
Javier Garau (Spain)
Peter Hermans (The Netherlands)
Walerie Hryniewicz (Poland)
Satoshi Iwata (Japan)
Jana Kozakova (Czech Republic)
Roman Kozlov (Russia)
Paula Krizova (Czech Republic)
Shabir Madhi (South Afrtica)
Jose Melo Cristino (Portugal)
Nobuhiko Okabe (Japan)
Kasunobu Ouchi (Japan)
Jordi Rello (Spain)
Markus Rose (Germany)
Isatou Sarr (UK)
Atef Shibl (Saudi Arabia)
Daniel Stecher (Argentina)
Robert Steffen (Switzerland)
Carla Vizzotti (Argentina)

How to Join

ISAC Working Groups are open to new members with a strong interest and relevant experience in the given field. To join an ISAC Working Group, please contact Fee Johnstone, ISAC Executive Officer with your name and a brief C.V. We welcome new members!

Aims and Objectives

To complement the work of the International Society of Antimicrobial Chemotherapy, an Immunisations and Vaccines Working Group has been formed. It consists of a group of world experts in vaccinology, immunology, public health and therapeutics.

We aim to foster the international exchange of ideas and new research into all aspects of vaccinology, from the development of new vaccines to epidemiology and immunobiology, moving through access, use and acceptance of vaccines.

Future / Ongoing Activities

  • Developing e-modules for the ISAC-Academy.
  • Prepare a workshop for regional meeting in Lebanon, March 2020 **Cancelled due to COVID-19**
  • Prepare the Tirana Albania workshop in March 2021 ****Cancelled due to COVID-19**
  • Provide submissions for ICC Perth 2021 **postponed until November 2022**


September 2015

ICC/ICAAC 2015, San Diego - 

1) Meningococcal symposium (Jessica MacNeil, Scott Halperin, Paul Kristiansen, Paul Offit, Markus Rose)

2) Pertussis meet-the-experts

3) Healthcare-associated infection symposium

Projects / Publications

Chris Blyth                                
  • Hansford, J.R., Phillips, M., Cole, C., Francis, J., Blyth, C.C., Gottardo, N.G. 2014, 'Bacillus Cereus bacteremia and multiple brain abscessess during acute lymphoblastic leukemia induction therapy', JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, online, pp. 5pp. Detail
  • Moore, H.C., Lehmann, D., De Klerk, N.H., Smith, D.W., Richmond, P.C., Keil, A.D., Blyth, C.C. 2014, 'How Accurate Are International Classification of Diseases-10 Diagnosis Codes in Detecting Influenza and Pertussis Hospitalizations in Children?', Journal of the Pediatric Infectious Diseases Society, Online, pp. 6pp. Detail
  • Ingram, P.R., Cheng, A.C., Murray, R.J., Blyth, C.C., Walls, T., Fisher, D.A., Davis, J.S. 2014, 'What do infectious diseases physicians do? A 2-week snapshop of inpatient consultative activities across Australia, New Zealand and Singapore.', CLINICAL MICROBIOLOGY AND INFECTION, 2014, pp. 8. Detail
  • Blyth, C.C., Richmond, P.C., Jacoby, P.A., Thornton, P., Regan, A.K., Robins, C., Kelly, H.A., Smith, D.W., Effler, P.V. 2014, 'The impact of pandemic A(H1N1)pdm09 influenza and vaccine-associated adverse events on parental attitudes and influenza vaccine uptake in young children', Vaccine, 32, 32, pp. 4075-4081. Detail
  • Moore, H.C., Jacoby, P.A., Hogan, A.B., Blyth, C.C., Mercer, G.N. 2014, 'Modelling the seasonal epidemics of respiratory syncytial virus in young children', PLoS ONE, 9, 6, Detail
  • 'Ahead of consensus: a paediatric antifungal prophylaxis census' in the Internal Medicine Journal 2015; 45(3): 364-365
Pablo Bonvehi
Robert Cohen
  • Cohen R, Bingen E, Levy C, Thollot F, Boucherat M, Drrkx V, Varon E. 'Nasopharynveal flora in children with acute otitis media before and after implementation of 7 valent pneumococcal conjugate vaccine in France'. BMC Infectious Diseases 2012; 12: 52.


  • Dagan R, Pelton S, Bakaletz L, Cohen R. 'Prevention of early episodes of otitis media by pneumococcal vaccines may reduce progression to complex otitis media'. The Lancet Infectious Diseases 2016;16:480-492.
  • Leshem E, Givon-Lavi N, Tate JE, Greenberg D, Parashar UD, Dagan R. 'Real-world effectiveness of pentavalent rotavirus vaccine among Bedouin and Jewish children in southern Israel'. Clinical Infectious Diseases 2016;62(S2):S155-60.
  • Dagan R, Ashkenazi S, Livni G, Go O, Bagchi P, Sarnecki M. 'Long-term serological follow-up of children vaccinated with a pediatric formulation of virosomal hepatitis A vaccine administered with routine childhood vaccines at 12-15 months of age'. Pediatr Infect Dis J 2016;35:e220-8.
  • Esposito S, Bonanni P, Maggi S, Tan L, Ansaldi F, Lopalco PL, Dagan R, Michel JP, van Damme P, Gaillat J, Prymula R, Vesikari T, Mussini C, Frank U, Osterhaus A, Pastore Celentano L, Rossi M, Guercio V, Gavazzi G. 'Recommended immunization schedules for adults: Clinical practice guidelines by the ESCMID vaccine study group (EVASG), European Geriatric Medicine Society EUGMS) and the World Association for Infectious Diseases and Immunoligical Disorders (WAidid). Human Vaccines and Immunotherapeutics 2016';12:1777-1794.
Javier Garau
  • Garau J, Ostermann H, Medina J, Avila M, McBride K, Blasi F, REACH Study Group. 'Current management of patients hospitalized with complicated skin and soft tissue infections across Europe (2010-2011)': assessment of clinical practice patterns and real-life effectiveness of antibiotics from the REACH Study. Clinical Microbiology and Infection 2013; 19(9): e377-85.
  • Monistrol O, Calbo E, Riera M, Nicolas C, Font R, Freixas N, Garau J. 'Impact of hand hygiene educational programme on hospital-acquired infections in medical wards'. Clinical Microbiology and Infection 2012; 18(12): 1212-8.
  • Antibiotic treatment of complicated skin and soft tissue infection (the REACH Study) in BMC ID 19th February 2015
  • Humphreys H, Becker K, Dohmen PM, Petrosillo N, Spencer M, van Rijen M, Wechsler-Fördös A, Pujol M, Dubouix A, Garau J. 'Staphylococcus aureus and surgical site infections: benefits of screening and decolonization before surgery'. J Hosp Infect. 2016 Jun 18. pii: S0195-6701(16)30165-7. doi: 10.1016/j.jhin.2016.06.011. [Epub ahead of print] Review. PMID: 27424948 [PubMed - as supplied by publisher]
  • Amaro R, Liapikou A, Cilloniz C, Gabarrus A, Marco F, Sellares J, Polverino E, Garau J, Ferrer M, Musher DM, Torres A. 'Predictive and prognostic factors in patients with blood-culture-positive community-acquired pneumococcal pneumonia.' Eur Respir J. 2016 May 12. pii: ERJ-00039-2016. doi: 10.1183/13993003.00039-2016. [Epub ahead of print] PMID: 27174880 [PubMed - as supplied by publisher]
  • Sangil A, Xercavins M, Rodríguez-Carballeira M, Andrés M, Riera M, Espejo E, Pérez J, Garau J, Calbo E. 'Impact of vaccination on invasive pneumococcal disease in adults with focus on the immunosuppressed.' J Infect. 2015 Oct;71(4):422-7. doi: 10.1016/j.jinf.2015.07.004. Epub 2015 Jul 18. PMID: 26192199 [PubMed - indexed for MEDLINE]
Peter Hermans
  • Cron LE, Stol K, Burghout P, van Selm S, Simonetti ER, Bootsma HJ, Hermans PW. 'Two DHH Subfamily 1 Proteins Contribute to Pneumococcal Virulence and Confer Protection against Pneumococcal Disease'. Infect Immun 79:3697-710, 2011.
  • de Gouw D, Diavatopoulos DA, Bootsma HJ, Hermans PW, Mooi FR. 'Pertussis: a matter of immune modulation'. FEMS Microbiol Rev. 35:441-74, 2011
  • Davila S, Wright VJ, Khor CC, Sim KS, Binder A, Breunis WB, Inwald D, Nadel S, Betts H, Carrol ED, de Groot R, Hermans PW, Hazelzet J, Emonts M, Lim CC, Kuijpers TW, Martinon-Torres F, Salas A, Zenz W, Levin M, Hibberd ML; 'Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease.International Meningococcal Genetics Consortium'. Nat Genet. 42:772-6, 2010
  • Burghout P, Cron LE, Gradstedt H, Quintero B, Simonetti E, Bijlsma JJ, Bootsma HJ, Hermans PW. 'Carbonic anhydrase is essential for Streptococcus pneumoniae growth in environmental ambient air' J Bacteriol 192:4054-62, 2010.
  • Sanchez CJ, Shivshankar P, Stol K, Trakhtenbroit S, Sullam PM, Sauer K, Hermans PW, Orihuela CJ. 'The pneumococcal serine-rich repeat protein is an intra-species bacterial adhesin that promotes bacterial aggregation in vivo and in biofilms'. PLoS Pathog. 12;6, 2010.
Satoshi Iwata
  • Ubukata K, Chiba N, Hanada S, Morozumi M, Wajima T, Shouji M, Iwata S. 'Invasive Pneumococcal Diseases Surveillance Study Group.: Serotype Changes and Drug Resistance in Invasive Pneumococcal Diseases in Adults after Vaccinations in Children, Japan, 2010-2013'. Emerg Infect Dis. 2015 Nov;21(11):1956-65.
  • Iwata S, Kawamura N, Kuroki H, Tokoeda Y, Miyazu M, Iwai A, Oishi T, Sato T, Suyama A, François N, Shafi F, Ruiz-Guiñazú J, Borys D.: 'Immunogenicity and safety of the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) co-administered with DTPa vaccine in Japanese children: A randomized, controlled study'. Hum Vaccin Immunother. 2015;11(4):826-37.
Walerie Hryniewicz
  • Skoczyńska A, Kuch A, Waśko I, Golębiewska A, Ronkiewicz P, Markowska M, Wasiak K, Hyrniewicz W.  'Invasive meningococcal disease in patients under 20 years of age in Poland 2009-2011'. Pediatria Polska 2012; 87(5): 438-43.
  • Skoczynaska A, Wasko I, Kuch A, Kadlubowski M, Golebiewska A, Forys M, Markowska M, Ronkiewicz P, Wasiak K, Kozinska A, Matynia B, Hryniewicz W, participants of a laboratory-based surveillance of community acquired invasive bacterial infections (BINet). 'A decade of invasive meningococcal disease surveillance in Poland'. PLoS ONE 2013; 8(8): e71943.
Satoshi Iwata
  • Matsubara K, Fujino M, Takeuchi K, Iwata S, Nakayama T. 'A new method for detection of neutralizing antibodies against mumps virus'. PLoS ONE 2013; 8(7): e65281.
  • Article on the genetic analysis of resistant Moraxella catarrhalis in the Journal of Infection and Chemotherapy April 2015
Roman Kozlov
  • Edelstein MV, Skleenova EN, Schevchenko OV, D’Souza JW, Tapalski DV, Azizov IS, Sukhorukova MV, Pavlukov RA, Kozlov RS, Toleman MA, Walsh TR. 'Spread of extensively resistant VIM-2 positive ST235 Pseudomonas aeruginosa in Belarus, Kazakhstan, and Russia: a longitudinal epidemiological and clinical study'. Lancet Infectious Diseases 2013; 13(10): 867-76.
Shabir Madhi
  • Schrag SJ, Cutland CL, Zell ER, Kuwanda L, Buchmann E, Velaphi SC,Groome MJ, Madhi SA. 'Risk factors for neonatal sepsis and perinatal death among infants enrolled in the Prevention of Perinatal Sepsis Trial, Soweto, South Africa'. Pediatr Infect Dis J; 2012, 2012, 31 (8): 821-6
  • Kiser JJ, Zhu R, D’Argenio DZ, Cotton M, Bobat R, McSherry G, Madhi S, Carey V, Seifart H, Werely C, Fletcher CV.Isoniazid pharmacokinetics and dosing in South African infants. Therapeutic Drug Monitoring 2012; 36 (4): 446-451.
  • Laughton B, Cornell M, Grove D, Kidd M, Springer PE, Dobbels E, Janse van Rensburg A, Violari A, Babiker AG, Madhi SA, Jean-Phillipe P, Gibb DM, Cotton MF. 'Early antiretroviral therapy improves neurodevelopmental outcomes in infants'. AIDS; 2012; 26 (13): 1685-1690.
  • Bottomley MJ, Serruto D , Sáfadi MAP, Klugman KP (2012) 'Future challenges in the elimination of bacterial meningitis'. Vaccine; 30S: B78 – B86.
  • Soeters HM, von Gottberg A, Cohen C, Quan V, Klugman KP (2012) 'Trimethoprim-sulfamethoxazole prophylaxis and antibiotic non-susceptibility in invasive pneumococcal disease'. Antimicrob Agents Chemother; 56: 1602 – 1605.
  • Keddy KH, Sooka A,Crowther P,Quan V, Meiring S, Cohen C, Nana T,Sriruttan C, Seetharam S,Hoosen A, Naicker P, Elliott E, Haffejee S, Whitelaw A, Klugman KP, 'For the Group for Enteric, Respiratory and Meningeal Disease Surveillance in South Africa (GERMS-SA) (2012)Systemic shigellosis in South Africa'.Clin Infect Dis; 54: 1448 – 1454.
  • Song JH, Dagan R, Klugman KP, Fritzell B (2012) 'The relationship between pneumococcal serotypes and antimicrobial resistance'. Vaccine; 30: 2728 - 37.
  • Sinha A, Kim S, Ginsberg G, Franklin H, Kohberger R, Strutton D, Madhi SA, Griffiths UK, Klugman KP (2012) 'Economic burden of acute lower respiratory tract infection in South African children'. PaediatrInt Child Health; 32: 65 – 73.
  • du Plessis M, Moodley C, Mothibeli KM, Fali A, Klugman KP, von Gottberg A (2012) 'Population snapshot of invasive serogroup B meningococci in South Africa from 2005 to 2008'. J Clin Microbiol; 50: 2577 – 2584.
  • Penny Crowther-Gibson, Cheryl Cohen, Keith P. Klugman, Linda de Gouveia, and Anne von Gottberg for the Group for Enteric, Respiratory, and Meningeal Disease Surveillance in South Africa (GERMS-SA) 'Risk Factors for Multidrug-Resistant Invasive Pneumococcal Disease in South Africa, a Setting with High HIV Prevalence, in the Prevaccine Era from 2003 to 2008'. Antimictobial Agents and Chemotherapy;56(10):5088-5095.
E.D McIntosh
  • Bröker M, Costantino P, De Tora L, McIntosh ED, Rappuoli R. 'Biochemical and biological characteristics of cross-reacting material 197 (CRM197), a non-toxic mutant of diphtheria toxin: use as a conjugation protein in vaccines and other potential clinical applications'. Biologicals 2011; 39: 195-204
  • Isaacman D, McIntosh ED, Reinert RR. 'Burden of invasive pneumococcal disease and serotype distribution among Streptococcus pneumoniae isolates in young children in Europe: impact of the seven-valent pneumococcal conjugate vaccine and considerations for future conjugate vaccines'. International Journal of Infectious Diseases 2010; 14: e197-e209
  • McIntosh EDG, Reinert RR. 'Global prevailing and emerging paediatric pneumococcal serotypes'. Expert Review of Vaccines 2010; 10: 109-129
  • Sáfadi MAP, McIntosh EDG. 'Epidemiology and prevention of meningococcal disease: a critical appraisal of vaccine policies'. Expert Review of Vaccines 2011; 10: 1717-1730
  • Dull PM, McIntosh ED. 'Meningococcal vaccine development – from glycoconjugates against MenACWY to proteins against MenB – potential for broad protection against meningococcal disease'. Vaccine 2012; 30S: B18-B25
  • Wassil J, McIntosh ED, Serruto D, Abitbol V, DeTora L, Bröker M, Kimura A. 'Progress toward the development of a multicomponent vaccine against meningococcal serogroup B (4CMenB)'. Clinical Investigation 2012; 2(5): 503-517
  • Türel Ő, Kisa A, McIntosh EDG, Bakir M. 'Potential cost-effectiveness of pneumococcal conjugate vaccine (PCV) in Turkey'. Value in Health 2013; 16(5): 755-759.
  • McIntosh EDG, Janda J, Ehrich JHH, Pettoello-Mantovani M, Somekh E. 'Vaccine hesitancy and refusal'. J Pediatrics 2016; 175: 248-249.
Jose Melo Cristino
  • Olafsdottir LB, Erlendsdottir H, Melo Cristino J, Weinberger DM, Ramirez M, Kristinsson KG, Gottfredsson M. 'Invasive infections due to Streptococcus pyogenes: seasonal variation of severity and clinical characteristics, Iceland, 1975 to 2012'. Eurosurveillance: European Communicable Disease Bulletin 2014; 19(17): 5-14.
  • Aguiar SI, Brito MJ, Horacio AN, Lopes JP, Ramirez M, Melo-Cristino J. Portuguese Group for the Study of Streptococcal Infections. Portuguese Study Group of Invasive Pneumococcal Disease of the Paediatric Infectious Disease Society. 'Decreasing incidence and changes in serotype distribution of invasive pneumococcal disease in persons aged under 18 years since introduction of 10-valent and 13-valent conjugate vaccines in Portugal, July 2008 to June 2012'. Eurosurveillance: European Communicable Disease Bulletin 2014; 19(12): 20750.
Hiroshige Mikamo
  • Umemura T, Yamagishi Y, Hamada Y, Suematsu H, Mikamo H. 'Investigation of the risk factors of anaerobic bacteremia in a case-control study'. Japanese Journal of Antibiotics 2014; 67(2): 133-43.
  • Management bundles for candidaemia – the ACTIONs project” in JAC vol 70 February 2015
Nobuhiko Okabe
  • Nabae, K. Takahashi, M. Wakui, T. Kamiya, H. Nakashima, K. Taniguchi, K. Okabe, N. 'A Shiga toxin-producing Escherichia coli O157 outbreak associated with consumption of rice cakes in 2011 in Japan'. Epidemiology and Infection 2013; 141(9): 1897-904.
Mario Ramirez
  • J. A. Carriço, A. Sabat , A. Friederich, M. Ramirez, on behalf of the ESCMID Study Group for Epidemiological Markers (ESGEM). 2013. 'Bioinformatics in bacterial molecular epidemiology and public health: databases, tools and the next-generation sequencing revolution'. Euro Surveill. 2013. 18:pii=20382
Jordi Rello
  • Lujan M, Burgos J, Gallego M, Falco V, Bermudo G, Planes A, Fontanals D, Peghin M, Monso E, Rello J. 'Effects of immunocompromised and comorbidities on pneumococcal serotypes causing invasive respiratory infection in adults: implications for vaccine strategies'. Clinical Infectious Diseases 2013; 57(12): 1722-30.
  • Understanding the concept of healthcare associated pneumonia (HCAP) in lung transplant patients” in Chest on 5th March 2015
Markus Rose
  • Rose MA, Damm O, Greiner W, Knuf M, Wutzler P, Liese JG, Krűger H, Wahn U, Schaberg T, Schwehm M, Kochmann TF, Eichner M. 'The epidemiological impact of childhood influenza vaccination using live-attenuated influenza vaccine (LAIV) in Germany: predictions of a simulation study'. BMC Infectious Diseases 2014; 14: 40.
Atef Shibl
  • Shibl A, Tufenkeji H, Khalil M, Memish Z, Meningococcal Leadership Forum (“MLF”) Expert Group. 'Consensus recommendation for meningococcal disease prevention in children and adolescents in the Middle East region. Journal of Epidemiology and Global Health 2012'; 2(1): 23-30.
  • Shibl AM, Memish ZA, Al-Kattan KM. 'Antibiotic resistance and serotype distribution of invasive pneumococcal diseases before and after introduction of pneumococcal conjugate vaccine in the Kingdom of Saudi Arabia (KSA)'. Vaccine 2012; 30 Suppl 6: G32-6.
Daniel Stecher
  • Stecher D, Gaiano A, Biscayart C, Gentile A, Ayala SG, Lopez E, Bonvehi P, Yedlin P, Janusz C, Vizzotti C. 'National Immunization Commission: strengthening evidence-based decision making in Argentina'. Vaccine 2014; 32(16): 1778-80.
Robert Steffen
Serhat Ünal
  • Ludwig E, Unal S, Bogdan M, Chlibek R, Ivanov Y, Kozlov R, et al. 'Regional advisory board position statement on optimal pneumococcal vaccination in adults. Update to 2011 consensus on adult pneumococcal disease: update on optimal pneumococcal vaccination in adults'. Central European Journal of Public Health 2013; 21(4): 233-6.
Carla Vizzotti
  • Biscayart C. Carrega ME. Sagradini S. Gentile A. Stecher D. Orduna T. Bentancourt S. Jimenez SG. Flynn LP. Arce GP. Uboldi MA. Bugna L. Morales MA. Digilio C. Fabbri C. Enria D. Diosque M. Vizzotti C. 'Yellow fever vaccine-associated adverse events following extensive immunization in Argentina'. Vaccine 2014; 32(11): 1266-72.

Last updated: February 26th-2024